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#HIGHEST DOSE OF TRAZODONE FOR INSOMNIA FULL#
#HIGHEST DOSE OF TRAZODONE FOR INSOMNIA TRIAL#
#HIGHEST DOSE OF TRAZODONE FOR INSOMNIA PLUS#

A full week supply of Trazodone should only cost a few dollars, compared to between $30 and $50 for other name brand sleeping agents.

Cost: The fact that this drug is generic means that its overall cost will be relatively low by comparison to name-brand sleeping pills (Z-drugs) like Lunesta, Rozerem, and Ambien.

There are several advantages associated with using Trazodone for the treatment of insomnia, despite the fact that it remains “off-label.” These advantages include things like: cost, efficacy, long-term effects, weight neutrality, and the fact that it can target multiple psychiatric conditions simultaneously. Potential Benefits of Trazodone for Insomnia At higher doses, Trazodone also would significantly inhibit serotonin by targeting both 5-HT2A and 5-HT2C (serotonin receptors) and may not be as effective. Specifically lower dosages of Trazodone tend to elicit effects of 5-HT2A antagonism, H1 receptor antagonism, and Alpha-1 adrenergic antagonism. A lower dose has a different mechanism of action than a higher one. When administered at low doses, Trazodone is considered an effective treatment for insomnia. Trazodone For Insomnia: A Popular Off-Label Option It is also believed that there is a relationship between the dose and the drug’s effect. This means that it primarily is thought to affect serotonin, with secondary effects on norepinephrine and histamine. The precise mechanism of action for Trazodone hasn’t been confirmed, but it is believed to affect a variety of receptor sites including: 5-HT1D, 5-HT1A, Alpha-1A, Alpha-2C, and H1.

#HIGHEST DOSE OF TRAZODONE FOR INSOMNIA PLUS#

It is considered considerably cheaper than most sleeping pills, plus it may be slightly safer than other traditional tranquilizing agents like benzodiazepines that are linked to dementia. Newer anecdotal evidence has even suggested that Trazodone’s off-label usage as a sleeping pill has surpassed its usage as an antidepressant.

Of all the off-label uses, arguably the most common is using Trazodone for insomnia or to help individuals facing an inability to fall asleep. The drug also is used on an off-label basis for the treatment of many conditions including: diabetic neuropathy, fibromyalgia, OCD, and alcohol withdrawal. It is considered a second generation antidepressant, and is still utilized primarily for the treatment of depression in patients that don’t respond well to newer medications (e.g. There was a significant decrease in the number of awakenings in patients receiving trazodone compared with placebo (SMD = −0.51 95% CI, −0.97 to −0.05), with no significant differences in other secondary outcomes.Trazodone (Desyrel) is classified as an atypical antidepressant, functioning specifically as an SARI (serotonin antagonist and reuptake inhibitor). Secondary outcomes included sleep latency, total sleep time, number of awakenings, and waking time after sleep onset. When trazodone was compared with placebo, there was no significant improvement in sleep efficiency (standardized mean difference = 0.09 95% CI, −0.19 to 0.38 P =.53) and small to no change in sleep quality (SMD = −0.41 95% CI, −0.82 to −0.00 P =.05). Primary outcomes included sleep efficiency and self-reported sleep quality. 1 Patients with insomnia were included regardless of whether it was primary or secondary insomnia.

#HIGHEST DOSE OF TRAZODONE FOR INSOMNIA TRIAL#

Six trials took place in the outpatient setting, and one trial combined inpatients and outpatients. A 2018 meta-analysis examining the use of trazodone for insomnia included seven RCTs with 429 adults (mean age = 46.1 years range = 38.2 to 81 years 58.2% female).